2021 Honda Odyssey MPG and Fuel Cost
The 2021 Honda Odyssey is rated 22 mpg combined in the one gas version EPA tested.
EPA fuel economy
2021 Honda Odyssey · 1 EPA-tested versionEPA rating
22MPG combined
19 city 28 highway
$2,950 a year to fuel
3.5L 6-cyl · FWD · 10-speed automatic
Best version costs $3,250 more in fuel over 5 years vs the average new vehicle (EPA)
Fuel cost: 15,000 miles a year at EPA's $4.32 a gallon (regular gas).
At EPA's price assumptions, fuel costs about $2,950 a year. Ratings for the best versions are unchanged from 2020.
Every 2021 Odyssey version
EPA's ratings for each version it tested. Fuel cost is EPA's estimate for 15,000 miles a year at its current prices.
| Version | Combined | City / Hwy | Fuel / year |
|---|---|---|---|
3.5L 6-cyl · FWD · 10-speed automatic
EPA listing: Odyssey |
22 mpg | 19 / 28 | $2,950 |
Fuel cost at your prices
EPA's annual cost uses 15,000 miles a year, 55% city driving and its current prices: $4.32 a gallon for regular gas. Change the numbers to match your driving.
| Version | Per year | 5 years |
|---|---|---|
3.5L 6-cyl · FWD · 10-speed automatic | $2,945 | $14,727 |
At the default settings the results match EPA's annual cost before EPA rounds it to the nearest $50.
Honda Odyssey MPG by model year
The best-rated version in each model year; the highlighted year is this page. Gas: 22 mpg (every year from 2016 to 2026).
2021: gas 22 mpgTap or drag across the chart for other years.
Show as a table
| Model year | Best gas version |
|---|---|
| 2016 | 22 |
| 2017 | 22 |
| 2018 | 22 |
| 2019 | 22 |
| 2020 | 22 |
| 2021 | 22 |
| 2022 | 22 |
| 2023 | 22 |
| 2024 | 22 |
| 2025 | 22 |
| 2026 | 22 |
How the 2021 Odyssey compares
2021 minivans covered on this site, ranked by their best combined rating. Fuel cost is for each model's cheapest version to run, at EPA's prices.
| 2021 model | Best combined | Best gas | Fuel / year |
|---|---|---|---|
Best: hybrid |
36 mpg | – | $1,800 |
Honda Odyssey This page Best: gas |
22 mpg | 22 mpg | $2,950 |
Best: gas |
22 mpg | 22 mpg | $2,950 |
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2021 Odyssey recalls and complaints
NHTSA lists 8 safety recalls and 141 owner complaints for the 2021 Odyssey.What they cover, and crash test ratingsQuestions
Does the 2021 Honda Odyssey need premium gas?
No. EPA lists every 2021 Honda Odyssey version on regular gasoline.
How does the 2021 Odyssey's MPG compare with the 2020?
For 2021, the best gas version is rated 22 mpg, the same as the year before.
Sources and method
- US EPA and Department of Energy fuel economy data (fueleconomy.gov), file dated Sep 18, 2026.
- EPA fuel price assumptions: regular $4.32, midgrade $4.93, premium $5.32, diesel $6.29 a gallon; electricity $0.15 per kWh.
- Recall and complaint counts: NHTSA recall file dated Sep 27, 2026 and complaint file dated Sep 26, 2026.
Ratings are EPA estimates. Real-world mileage depends on how, where and in what weather you drive. How we build these pages. Spotted an error? Tell us.